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YubiKey 4

Your users create and access a lot of your organization’s most important data on Salesforce.com The first step to protecting this data from unauthorized access is enabling two-factor authentication.

Use YubiKeys* for FIDO Universal 2nd Factor (U2F) authentication, or generating One-Time Passwords (OTP).

*YubiKey 4, YubiKey 4 Nano, YubiKey Neo, and the FIDO U2F Security Key.

Salesforce.com Winter ’17 Release (September 2016)

Salesforce completed integration of the FIDO Universal 2nd Factor (U2F) authentication standard in the Winter ’17 release. It’s a more secure, more convenient alternative to using Salesforce Authenticator or One-Time Passwords (OTP) sent by email or SMS.

Resources:
Knowledge Base: How to use U2F YubiKeys with Salesforce (for Administrators)
Salesforce: Enable U2F Security Keys for Identity Verification
Salesforce: Set Up Two-Factor Authentication

Salesforce.com Winter ’15 Release (January 2015)

Salesforce introduced two-factor authentication with One-Time Passwords (OTP) in the Winter ‘15 Release. As a Salesforce admin, you can allow users to authenticate with their YubiKey(s) any time they’re challenged to verify their identity.

Resources:
YubiKey for Salesforce on the Salesforce AppExchange
YubiKey for Salesforce Video
YubiKey for Salesforce Admin Guide
Integrate YubiKey for Salesforce
Salesforce Developers Login Flow Guide