Yes, the YubiKey can be used with any computer (including Mac) that has a standard USB 2.0 port and supports USB keyboards. The YubiKey identifies itself to the computer as a USB Keyboard, and is therefore OS independent. It works with Windows, Linux, OS X, iOS (iPad/iPad 2/iPad 3 only), PS3, Xbox360, Wii etc. without requiring the installation any device drivers.
Posted in: 2. The YubiKey